Villains who have the desire to take over the world; whether the actual Earth or their own world or an entire land. On larger scales, some try to take over their universe and, for the truly despotic, all of the omniverse.
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A
- A.I.M.
- A.I.M. (Yost Universe)
- Abomination
- Acronix
- Admiral Malkor
- Ahuizotl
- Aku
- Aku's Minions
- Aldrich Killian
- Alexander Pierce (Marvel Cinematic Universe)
- Allegra Gleaming
- Almighty Tallest Red and Purple
- Aloyse Von Roddenstein
- Alpha-1
- Alternate World Team Rocket
- Amon
- Ancestral Witches
-
- Annihilus (Yost Universe)
- Anti-Cosmo
- Apocalypse
- Archie
- Ares
- Ares (God of War)
- Aresia
- Arnim Zola (Marvel Cinematic Universe)
- Ash Delgado
- Aspheera
- Astronema
- Atrocitus
- Audrey (Descendants)
- Awful Alvin
- Azula
B
- Balthazar Bratt
- Baron Silas Greenback
- Baron Von Strucker (Yost Universe)
- Baron Wolfgang von Strucker
- Baron Zemo
- Baron Zemo (Yost Universe)
- Belle Bottom
- Ben Ravencroft
- Bentley and Buford Buzzard
- Bill Cipher
- Black Adam
- Black Doom
- Black Manta
- Black Order (Marvel)
- Blackbeard (Pan)
- Blackbeard's Crew (Pan)
- Blackfire
- Bling-Bling Boy
- Blizzard Samurai
- Bloth
- Bloth's Crew
- Boskov the Bear
- Boss Witch
- Bowser
- Bowser (Super Mario Bros. Movie)
- Bradford Buzzard
- Brain (Animaniacs)
- Brainiac
- Broccoloid Emperor
- Broccoloids
- Broly
- Broodwing's Forces
- Brotherhood of Mutants
- Buggler
C
- Cackletta
- Cahu
- Captain Hook
- Captain Mutiny
- Captain Mutiny's Crew
- Captain Salazar
- Caractacus P. Doom
- Cell
- Champa
-
- Chase Young
- Chernabog
- Chester Yapsby
- Chiros
- Chronos (DC)
- Cia
- Cobalt Blue
- Cobra Commander (G.I. Joe)
- Colonel Muska
- Constantine (Robotboy)
- Council of the Crystal King
- Count Dregon
- Count Dregon's Forces
- Count Marzo
- Count Vertigo (DC)
- Countess Cassandra
- Cozy Glow
- Crocodillia
- Crossbones
- Crystal Army
- Cult of Aku
- Cursa
- Cutler Beckett
- Cyber Shredder
- Cyrus
D
- Dabi (Tabbyverse)
- Dai Shi
- Dai Shi Clan
- Dan Phantom
- Dark Duo (D. Xenon/Philmac Zomdroid)
- Dark Elves
- Dark Laser
- Dark Oak
- Dark Specter
- Darkdream
- Darkonda
- Darkseid
- Darkseid (DC Animated Universe)
- Darkseid's Elite
-
- Darth Vader
- De'Cine
- Deathstroke
- Deimos (DC)
- Delightful Reaper
- Demons (Power Rangers)
- Denzel Crocker
- Derek (Milo Murphy's Law)
- Despero (DC Animated Universe)
- Dimentio
- Dino Troopers (DC)
- Divatox's Crew
- Doctor Octopus
- Doctor Undergear
- Doctor Zoog
- Dogbert
- DOR-15
- Dormammu
- Dr. Animo
- Dr. Biron Sakitron
- Dr. Carver (clone)
- Dr. Claw
- Dr. Doom
- Dr. Drakken
- Dr. Eggman
- Dr. Emmanuel Klipse
- Dr. Hamsterviel
- Dr. Kamikazi
- Dr. Neo Cortex
- Dr. Nogood
- Dr. Puzzle (The Garfield Show)
- Dr. Robotnik
- Dr. Robotnik (AoStH)
- Dr. Sivana
- Dr. Viper
- Dr. Wily
- Dr. Z
- Drago Bludvist
- Drakken Joe
- Drex
- Duke Igthorn
- Duke of Zill
E
- East India Trading Company (Pirates of the Caribbean)
- Eduardo Perez
- Ego
- Ego (Marvel Cinematic Universe)
- Eklipse
- Ember McLain
- Emperor Gruumm
- Emperor Maltazard
- Emperor Mavro
- Emperor Nefarious
- Emperor of the Night
- Emperor Palpatine (Darth Sidious)
- Emperor Zurg (Buzz Lightyear of Star Command)
- Erik Killmonger (Marvel Cinematic Universe)
- Erik Killmonger (Marvel)
- Eris
- Esme Jadespark
- Esmeralda Poofenplotz
- Etemon
- Evanora (Oz the Great and Powerful)
- Evil Buzz Lightyear
- Evil Entity
- Evil Horde
- Evil Space Aliens (Power Rangers)
- Evil Warriors
- Evilseed
- Evox Virus Army