Characters who are the nephews of other characters.
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- Sandy Ricks
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- Sarah and James
- Scooter (Muppets)
- Scrappy-Doo
- Scruff (McGruff the Crime Dog)
- Shang-Chi
- Shaun the Sheep
- Shining Armor
- Sid
- Sid Jones (TMNT)
- Simba
- Simba (2019)
- Skid McMarx
- Skippy Squirrel
- Snively Robotnik
- Snotlout
- Sonic the Hedgehog
- Spider-Man
- Spider-Man (Marvel Cinematic Universe)
- Spider-Man (Miles Morales)
- Spike the Dragon
- SpongeBob SquarePants
- Spyke
- Stinky
- Stuart Little
- Super Jetstream
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- T.C.
- Tadashi Hamada
- Takeru ''T.K.'' Takaishi
- Talking Ginger
- Talon
- Terramar
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- The Riveras
- The Willie Brothers
- Thomlight Sparkle
- Thoren
- Thrax (PR)
- Thumper
- Thunder Spectrum
- Thunder Storm
- Thunder-Karlsson and Bloom
- Timon
- Tommy Pickles
- Tony Zucco (DC)
- Toucan Sam's Nephews
- Treasurer
- Tritannus
- Trunks
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