Lord Osmund Saddler is the main antagonist of the 2005 survival horror game Resident Evil 4 and its 2023 remake. The leader of the religious cult Los Iluminados that rules over the Spanish town of Valdelobos, Osmund Saddler had the daughter of the US president kidnapped as part of his plans for world domination. Holding supreme power over the Las Plagas parasites, Saddler intended to use her to spread his influence across the United States and then the entire world.
While Saddler merely used his religion as a means to control his cult in the original 2005 game, the 2023 remake changed Saddler into the latest in a long line of true believers, viewing the Las Plagas as holy creatures that will unite the world in everlasting peace under his rule. Although Saddler was killed and his plans foiled, Las Plagas later became a staple of the global bio-weapon black market.
In Japanese, he is voiced by Hōchū Ōtsuka in the 2023 remake. In English, he was voiced by Michael Gough in the original game and Christopher Jane in the 2023 remake.