Having spent a good deal of time enjoying the company of their newfound family and friends at Witch Mountain and intensively studying and practicing their supernatural powers, it is decided that Tony and Tia, with their cousin Crystal and her dog Amber helping them once again, deserve a vacation in Los Angeles, California. Uncle Bené drops them off in their flying saucer in the Rose Bowl Stadium, after which they reunite with Winnie the Pooh, Piglet, Tigger, Rabbit, Eeyore, Kanga, Roo, Lumpy, Darby, Buster, Ash Ketchum, Pikachu, Misty, Brock, Togepi, Simba, Nala, Timon, Pumbaa, The Vultures (Buzzie, Flaps, Ziggy, and Dizzy), Jiminy Cricket, Zazu, Scooby-Doo, Shaggy, Fred, Daphne, Velma, Genie, Iago, and Chanticleer and quickly become separated from each other. Dr. Gannon and Letha, whom Scar, Shenzi, Banzai, Ed, The Grand Duke of Owls, and Team Rocket (Jessie, James, and Meowth) work for, happen to see Tony using his powers, kidnap him, and successfully test the doctor's new mind-control technology on him. With Tony at his robotic bidding, Dr. Gannon hopes to achieve recognition within the scientific community and worldwide power, while Letha merely wants a return on her investment.
Tia, Pooh, Ash, Simba, Scooby-Doo, and the rest must find Tony and foil the villains' nefarious plans. Fortunately, a group of would-be toughs, called the Earthquake Gang, and hapless truant officer Mr. Yokomoto — whom the toughs call "Yo-Yo" — come to her aid.
- Ash Ketchum, Pikachu, Misty, Brock, Togepi, Simba, Nala, Timon, Pumbaa, The Vultures (Buzzie, Flaps, Ziggy, and Dizzy), Jiminy Cricket, Zazu, Scooby-Doo, Shaggy Rogers, Fred Jones, Daphne Blake, Velma Dinkley, Crystal, Amber, Genie, Iago, Chanticleer, Scar, Shenzi, Banzai, Ed, The Grand Duke of Owls, and Team Rocket (Jessie, James, and Meowth) guest star in this film.
- This is an NTSC film with NTSC bits from the Winnie the Pooh movies, the Pokémon movies, The Jungle Book 1 and 2, Pinocchio, The Lion King trilogy, the Scooby-Doo movies, the Aladdin trilogy, Mickey's Christmas Carol, and Rock-a-Doodle.